Nattokinase and Blood Clots















Nattokinase and blood clots …. For over 1000 years a fermented cheese-like food called natto has been used in Japan. It’s been a folk remedy for heart and vascular diseases. The natto is produced by adding Bacillus natto to boiled soybeans and the result is the nattokinase enzyme. Nattokinase was discovered in 1980 by Dr. Hiroyuki Sumi, when he was working as a researcher at Chicago University Medical School. He was majoring in physiological chemistry. He’d been, for a long time, researching thrombolytic enzymes for a natural agent that could be used to dissolve blood clots associated with heart attacks and strokes.

After Sumi tested over 173 natural foods, he dropped natto onto artificial thrombus or fibrin in a Petri dish and allowed it to stand at approximately body temperature. The thrombus that was around the natto slowly dissolved and eventually after 18 hours was completely dissolved. Sumi named his newly discovered enzyme nattokinase, which means enzyme in natto. He commented that it showed a “potency matched by no other enzyme.”


Blood Clot Formation, Showing Trapped Red Blood Cells or Erythrocytes in Fibrin
Blood Clot Formation, Showing Trapped Red Blood Cells or Erythrocytes in FibrinPhotographic Print
Caughey, Robert
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The body makes several types of enzymes to produce thrombus, but only one enzyme to dissolve it. That enzyme is plasmin. The properties of natto resemble plasmin. Dr. Martin Milner of the Center for Natural Medicine in Portland, states that nattokinase is a potent treatment because it fights the clots in several ways. First it dissolves the clot directly, second it enhances the body’s production of plasmin and other clot-dissolving agents such as urokinase. Dr. Milner also states that nattokinase is superior to conventional clot-dissolving drugs as they are only effective when taken intravenously and they often fail because the patient’s arteries have hardened to the point where the drug is not effective. Nattokinase can help prevent that hardening with as little as 100mg a day. Nattokinase has a prolonged action because it prevents coagulation of blood and it dissolves already existing blood clots. Drugs wear off shortly after discontinuation of IV treatment.


Blood Clot Formation, Showing Trapped Red Blood Cells or Erythrocytes in Fibrin
Blood Clot Formation, Showing Trapped Red Blood Cells or Erythrocytes in Fibrin

Photographic Print
Phillips, David
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Dr. Milner along with Dr. Kouhei Makise of the Imadeqawa Makise Clinica in Kyoto, Japan were able to embark on a joint research project on nattokinase and write an extensive paper on their findings. Nattokinase has been the subject of 17 studies, which includes two small human studies. One study involving dogs revealed by angiograms that the dogs who received nattokinase regained normal clot-free circulation within five hours of treatment. The dogs who received placebos didn’t show any sign of clot dissolution after 18 hours.


Normal Artery, Cross Sectn Photomic-Color
Normal Artery, Cross Sectn Photomic-Color

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It’s important that individuals who are receiving drugs from their physicians for blood clots not self–treat with nattokinase. Speak to your doctor about your desire to try nattokinase as using nattokinase with your medication could cause serious problems.


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The information on enzyme-facts.com is not offered for the diagnosis, cure, mitigation, treatment, or prevention of any disease or disorder nor have any statements herein been evaluated by the Food and Drug Administration (FDA). We strongly encourage you to discuss topics of concern with your health care provider.

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